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Augmenting Language Therapy for Aphasia: A Randomized Double-Blind Placebo-Controlled Trial of Levodopa in Combination with Speech-Language Therapy

Objective

There is preliminary evidence that increased levels of dopamine may improve learning following stroke. This study evaluates whether a pharmacologic agent, levodopa, can help increase the amount of improvement that may be achieved during speech and language therapy for individuals with non-fluent aphasia.  The speech-language treatment is done on a computer program that allows individuals with aphasia to practice reading aloud sentences together with an animated “therapist” on the computer. 

IRB Protocol Number
STU00001665
Principal Investigator(s)
Leora Cherney

Clinical Trial Categories

  • Stroke Research
  • Aphasia Research

Compensation

  • Not Provided
Sponsor(s)
The National Institute on Disability and Rehabilitation Research (NIDRR)
Contact
Center for Aphasia Research at 312-238-6163
How to Participate
  • Individuals with non-fluent aphasia following a stroke
  • Must be at least 6 months since stroke onset

Compensation

  • Travel and parking expenses reimbursed for the assessments.  
  • No compensation provided for the treatment sessions.

Location

  • Rehabilitation Institute of Chicago (RIC)
    345 East Superior Street
    Chicago, IL 60611
    Main: 312-238-1000