To understand how neurological impairment affect muscles at the sarcomere and sub-sarcomere levels, which will help us develop more effective treatment in a related study for patients with spasticity and contracture caused by CNS pathology. As a participant in this study you will be asked to allow us to test the property of a tiny bundle of fibers in your muscle involved in the surgery.
Either needs to be healthy or have a neurological impairment or has orthopedic surgery schedule. Patients with neurologically disorders who have spastic/stiff joint and are scheduled to have surgical procedures includingtendon/muscle lengthening and tendon transfer will be recruited in the proposed study. In addition, patients who do not have neurological disorders but scheduled for surgeries on the limb for sports-related injuries or fractures (e.g., tibial/fibular fracture, ankle fracture, humeral fracture and radial/fibular fracture) will also be recruited as controls.
Compensation is $100