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Fri, May 21

Speaker: Shailesh Kantak, PhD (Postdoctoral Candidate)

Title: Neural substrates of motor memory consolidation: A double dissociation of primary motor cortex and dorsolateral prefrontal cortex induced by practice structure

Abstract: Motor practice drives subsequent offline activity within functionally related resting brain networks. Little is known about how offline neural networks are modulated by practice structures known to affect motor skill learning. To investigate the neural correlates of motor memory consolidation, we applied 1 Hz repetitive Transcranial Magnetic Stimulation (rTMS) immediately after a bout of constant or variable motor practice to disrupt either primary motor cortex (M1) or dorsolateral prefrontal cortex (DLPFC), two putative nodes previously shown to be engaged in early consolidation. Motor learning was assessed the following day through a performance-based retention test. Immediately after constant practice, rTMS to M1, but not DLPFC attenuated retention of the motor skill. In contrast, immediately after variable practice, rTMS to DLPFC, but not M1 attenuated retention performance. These findings provide evidence that for motor skills, the neural substrates of motor memory consolidation are modulated by practice structure.

Host: Jim Stinear