Lee Miller, PhD - Rehabilitation Institute of Chicago

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  • Only Hospital Ranked #1 in America by U.S. News & World Report since 1991
  • 800,000+ outpatient visits each year
  • 5,000+ inpatients treated each year, system-wide
  • 50+ sites of care throughout Illinois and Indiana
  • One of only 2% of hospitals to receive three consecutive Magnet Recognitions for Nursing Excellence.
  • 182-bed inpatient hospital in the heart of Chicago
  • Largest rehabilitation research center in the world
  • Only rehabilitation hospital with eight federally designated research centers
  • 370+ active research projects in neuroscience, bionics, robotics, and musculoskeletal medicine
  • Academic home of Physical Medicine & Rehabilitation Department, Northwestern University Feinberg School of Medicine

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Lee Miller

Lee Miller, PhD

  • Professor, PM&R and Physiology, Northwestern University
  • Edgar C. Stuntz Distinguished Professor of Neuroscience


Education, Residency and Internship


Goshen College, Goshen, Indiana, BA
Northwestern University, Evanston, Illinois, MS


Northwestern University, Evanston, Illinois, PhD
Department of Biophysics and Medical Physics,University of Nijmegen, The Netherlands, Post-Doctoral
Physiology Department, Northwestern University, Research Associate

Additional Information

Research Lab

Honors & Awards

2011 Appointed to Edgar C. Stuntz, Distinguished Professor of Neuroscience Chair

2002 Senior Visiting Fellow, Institute of Neurology, University College London

1996-1997 NATO International Scientific Exchange Programmes Collaborative Research Grant

1990-1992 European Community ESPRIT II Post-Doctoral Fellowship

1981-1982 Murphy Fellowship, Northwestern University

1978 Research Fellow, Turner Precision X-ray Measurements Lab., Goshen College


Zaaimi B, Ruiz-Torres R, Solla SA, Miller, LE (2013) Multi-electrode stimulation in somatosensory cortex increases probability of detection. J Neural Eng, October 2013.

Cherian A, Fernandes H, Miller LE (2013) Primary motor cortical discharge during force field adaptation reflects muscle-like dynamics. J Neurophysiol, May 2013.

London BM, Miller LE (2013) Responses of somatosensory area 2 neurons to actively and passively generated limb movements. J Neurophysiol 109 (6): 1505-1513.

Oby E, Ethier C, Miller LE (2013) Movement representation in the primary motor cortex and its contribution to generalizable EMG predictions. J Neurophysiol 109 (3): 666-678.

Ledbetter N, Ethier C, Oby E, Hiatt S, Wilder A, Ko J, Agnew S, Miller LE, Clark G (2013)Intrafascicular stimulation of monkey arm nerves evokes coordinated grasp and sensory responses.  J Neurophysiol 109 (2): 580-590.

Weber DJ, Friesen R, Miller LE (2012) Interfacing the somatosensory system: Essential considerations.J Motor Behavior 44 (6): 403-418.

Corbett E, Ethier C, Oby E, Körding K, Perreault E, Miller LE (2013) Advanced User Interfaces for Upper Limb FES. In: Introduction to Neural Engineering for Motor Rehabilitation, Farina, Jensen and Akay, Editors. IEEE/Wiley Press.

Stevenson IH, London BM, Oby ER, Sachs NA, Reimer J, Englitz B, David SV, Shamma SA, Blanche TJ, Mizuseki K, Zandvakili A, Hatsopoulos NG, Miller LE, Kording KP (2012) Functional Connectivity and Tuning Curves in Populations of Simultaneously Recorded Neurons. PLoS Comput Biol 8:e1002775.

Flint, R.D., Lindberg, E.W., Jordan, L.R., Miller, L.E., and Slutzky, M.W. (2012) Accurate decoding of reaching movements from field potentials in the absence of spikes. J Neural Eng 9: 046006.

Ethier C, Oby ER, Bauman MJ, Miller LE (2012) Restoration of grasp following paralysis through brain-controlled stimulation of muscles. Nature 485 (7398): 368-371.

Flint RD 3rd, Ethier C, Oby ER, Miller LE, Slutzky MW (2012) Local field potentials allow accurate decoding of muscle activity. J Neurophysiol 108 (1), 18-24.

Weber DJ, London BM, Hokanson JA, Ayers CA, Gaunt RA, Torres RR, Zaaimi B, Miller LE (2011) Limb-state information encoded by peripheral and central somatosensory neurons: implications for an afferent interface. IEEE Trans Neural Syst Rehabil Eng. 19 (5): 501-13.

Miller LE, Weber DJ (2011) Brain training: cortical plasticity and afferent feedback in brain-machine interface systems. IEEE Trans Neural Syst Rehabil Eng. 19 (5): 465-7.

London BM, Torres RR, Slutzky MW, Miller LE (2011) Designing stimulation patterns for an afferent BMI: Representation of kinetics in somatosensory cortex. 33rd Annual International IEEE EMBS Conference, Boston.

Sachs NA, Corbett EA, Miller LE, Perreault EJ (2011) Continuous movement decoding using a target-dependent model with EMG inputs. 33rd Annual International IEEE EMBS Conference, Boston.

Ackermann DA, Ethier C, Foldes EL, Oby ER, Tyler D, Bauman MJ, Bhadra N, Miller LE, Kilgore KL (2011) Electrical Conduction Block in Large Nerves: High Frequency Current Delivery in the Nonhuman Primate. Muscle & Nerve 43 (6): 897-899.

Slutzky MW, Jordan LR, Lindberg E, Miller LE (2011) Decoding rat forelimb movement direction from epidural and intracortical field potentials. J Neural Eng 8: 036013.

Cherian A, Krucoff MO, Miller LE (2011) Muscle activity decoded from M1 discharge remains stable despite altered limb dynamics and posture. J Neurophysiol 106:564-575.

Stevenson IH, Cherian A, London BM, Sachs NA, Lindberg E, Reimer J, Slutzky MW, Hatsopoulos NG, Miller LE, kording KP (2011) Statistical assessment of the stability of neural movement representations.J Neurophysiol 106:764-774.

Ethier C, Sachs NA, Miller LE (2011) Continuous State-dependent Decoders for Brain Machine Interfaces. In: The 5th International IEEE EMBS Neural Engineering Conference, Cancun.

Lindberg EW, Miller LE, Oby ER, Slutzky MW (2011) Decoding muscle activity with local field potentials. In: The 5th International IEEE EMBS Neural Engineering Conference, Cancun.

Rebesco JM, Miller LE (2011) Stimulus-driven changes in sensorimotor behavior and neuronal functional connectivity: Application to brain machine interfaces and neurorehabilitation. In: Enhancing performance for action and perception, vol. 192: 83-102, vol II. Elsevier.

Nazarpour K, Ethier C, Paninski L, Rebesco JM, Miall RC, Miller LE (2011) EMG prediction from Motor Cortical Recordings via a Non-Negative Point Process Filter. IEEE Trans Biomed Eng.

Rebesco JM, Miller LE (2011) Enhanced detection threshold for in vivo cortical stimulation produced by Hebbian conditioning. J Neural Eng 8: 016011.

Rebesco JM, Miller LE (2010) Altering Function in Cortical Networks by Short-Latency, Paired Stimulation. Conf Proc, IEEE Eng Med Biol Soc.

Oby ER, Ethier C, Bauman M, Perreault EJ, Ko J, Miller LE (2010) Prediction of Muscle Activity from Cortical Signals to Restore Hand Grasp in Subjects with Spinal Cord Injury. In: O'Weiss KG (ed) Statistical Signal Processing for Neuroscience and Neurotechnology. Academic Press, Elsevier.

Ethier C, Oby ER, Bauman M, Miller LE (2010) Cortically controlled functional electrical stimulation: a neuroprosthesis for grasp function. Conf Proc, 10th Vienna International Workshop on FES and 15th IFESS Annual Conference 2010.

Slutzky MW, Jordan LR, Bauman MJ, Miller LE (2010) A new rodent behavioral paradigm for studying forelimb movement. JNS Methods 192: 228-232.

Rebesco JM, Stevenson IH, Koerding K, Solla SA, Miller LE (2010) Rewiring neural interactions by micro-stimulation. Frontiers in Systems Neuroscience 4: 39.

Slutzky MW, Jordan LR, Miller LE (2010) Optimal spacing of surface electrode arrays for brain machine interface applications. J Neural Eng 7: 26004.

Perreault EJ, Ethier C, Pohlmeyer EA, Oby ER, Miller LE (2009) A Brain-Machine Interface for Restoring Hand Function Following Paralysis. Asilomar Conference on Signals, Systems and Computers.

Brill N, Polasek K, Oby E, Ethier C, Miller L, Tyler D (2009) Nerve cuff stimulation and the effect of fascicular organization for hand grasp in nonhuman primates. Conf Proc IEEE Eng Med Biol Soc 1: 1557-1560.

Holdefer RN, Miller LE (2009) Dynamic Correspondence between Purkinje Neuronal Discharge and Forelimb Muscle Activation in the Macaque. Brain Res 1295: 67-75.

Fagg AH, Ojakangas GW, Miller LE, Hatsopoulos NG (2009) Kinetic trajectory decoding using motor cortical ensembles. IEEE Trans Neural Syst Rehabil Eng 17: 487-496.

Fagg AH, Hatsopoulos NG, London BM, Reimer J, Solla SA, Wang D, Miller LE (2009) Toward a Biomimetic, Bidirectional, Brain Machine Interface. in: 31th Annual International IEEE EMBS Conference, Minneapolis. embc 2009 v13

Pohlmeyer EA, Jordon LR, Kim P, and Miller LE. (2009) A fully implanted drug delivery system for peripheral nerve blocks in behaving animals. Journal of neuroscience method. 182: 165-171. JNS Methods v182p165

Miller LE, Gibson A (2009) The Red Nucleus. In: Squire L (ed) The New Encyclopedia of Neuroscience. Elsevier Ltd, Oxford. pp 55-62. Ency NS v8p55

Pohlmeyer EA, Oby ER, Perreault EJ, Solla SA, Kilgore KL, Kirsch RF, Miller LE (2009) Toward the Restoration of Hand Use to a Paralyzed Monkey: Brain-Controlled Functional Electrical Stimulation of Forearm Muscles. PLoS ONE 4: e5924. PLoSONE v4e5924

Stevenson IH, Rebesco JM, Hatsopoulos NG, Haga Z, Miller LE, Kording KP (2009) Bayesian inference of functional connectivity and network structure from spikes. IEEE Transactions on Neural Systems and Rehabilitation Engineering 17, 203-213. IEEE TNSRE v17p203

Stevenson IH, Rebesco JM, Miller LE, Kording KP (2008) Inferring functional connections between neurons. Curr Opin NeuroBiol v18p582

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